Biomechanical Modeling, Simulation and Experimental Methods: From Cells to Organs
Art
Themenbereich
- Human & Biotechnology (Field of Expertise)
This is the 9th Summer School on Biomechanics in the series we have organized. Its aim is to provide a state-of-the-art overview of biomechanical modeling, simulation and experimental methods at different length scales.
The lectures will cover essential ingredients of continuum mechanics, nonlinear elasticity, and the finite element method including fluid-structure interactions (FSIs), with an emphasis on various aspects of mechanical and structural modeling of fiber-reinforced materials. Applications to soft tissues, arterial walls, aortic aneurysms (mechanics, mechanobiology and pathogenesis), aortic dissections and the heart are highlighted. Particular interest is also focused on the continuous and discrete mechanical modeling of collagen fiber dispersion including cross-linking, fiber recruitment and damage, and on cardiac cells with a focus on mechanosignaling, growth, remodeling and excitation-contraction.
In addition, the mechanics of collagen and elastin networks and the non-local damage and healing of soft tissues are studied. Applications of FSIs to the respiratory system are also discussed. Moreover, quantitative characterization and reduction of uncertainties in complex biomechanical applications are investigated (uncertainty quantification).
Experimental techniques for the determination of the mechanical properties of tissues, cells, cellular components, and proteins will be described. In particular, cell mechanics studies of malaria and cancer are presented and cell mechanics-based microfluidics for disease diagnosis and precision therapy are discussed. The important area of parameter identification is covered by using full-field optical measurements with the virtual fields method in elasticity.
Future directions and challenges will be identified during the lectures for research in biomechanics at multiple scales, and mechanobiology involving mechanical, biological, electrical and fluid-structure interactions.
Veranstaltet von
Gerhard A. Holzapfel, Ray W. Ogden
