SPiDR brings together the latest advances in wireless networking, localization, benchmarking, collaborative awareness, and machine learning, towards the development of secure, resilient, and highly-performant wireless mesh networks. Within SPiDR, we will create benchmarking infrastructures supporting experimentation on wireless networks based on Wi-Fi, Bluetooth Low Energy (BLE), and Ultra-wideband (UWB) technology; we will design dependable and scalable networking protocols that are resilient to malicious agents; we will provide autonomous entities such as drones with RF context- and location-awareness, as well as with the ability to identify and mitigate security threats, network anomalies, and coexistence issues.